| Pair Name | Apigenin, Doxorubicin | ||
| Phytochemical Name | Apigenin (PubChem CID: 5280443 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Apigenin, Doxorubicin | |||
| Disease Info | [ICD-11: 2C82] | Prostate cancer | Investigative | |
| Biological Phenomena | Inhibition-->Cell migration | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Up-regulation | Expression | CYCS | hsa54205 | |
| Down-regulation | Phosphorylation | MAPK1 | hsa5594 | |
| Down-regulation | Expression | MMP9 | hsa4318 | |
| Down-regulation | Phosphorylation | PIK3CA | hsa5290 | |
| Up-regulation | Expression | PSMD9 | hsa5715 | |
| Up-regulation | Expression | PTEN | hsa5728 | |
| Down-regulation | Expression | SNAI1 | hsa6615 | |
| Down-regulation | Expression | TWIST1 | hsa7291 | |
| In Vitro Model | PC-3 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0035 |
| Result | Co-administration of apigenin with doxorubicin enhances anti-migration and antiproliferative effects via PI3K/PTEN/AKT pathway in prostate cancer cells | |||
| No. | Title | Href |
|---|---|---|
| 1 | Co-administration of apigenin with doxorubicin enhances anti-migration and antiproliferative effects via PI3K/PTEN/AKT pathway in prostate cancer cells. Exp Oncol. 2021 Jun;43(2):125-134. doi: 10.32471/exp-oncology.2312-8852.vol-43-no-2.16096. | Click |
